Get Amino Acids, Peptides and Proteins (SPR Amino Acids, PDF

By John S. Davies

ISBN-10: 0854042520

ISBN-13: 9780854042524

Fundamental reference resource for researchers within the pharmaceutical and allied industries, and on the biology/chemistry interface in academia. summary: fundamental reference resource for researchers within the pharmaceutical and allied industries, and on the biology/chemistry interface in academia. learn more...

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Extra info for Amino Acids, Peptides and Proteins (SPR Amino Acids, Peptides, and Proteins (RSC)) (Vol 36)

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69 The synthesis of enantiopure g-substituted g-amino acids with proteinogenic side chains, starting from the corresponding natural a-amino acids, was studied. N-Protected amino aldehydes containing various protective groups were directly reacted with methyl, benzyl, and tert-butyl phosphoranylidene acetate to produce a,b-unsaturated g-amino esters. 170 Recently, b-hydroxy-g-amino acids have received considerable attention, notably those acting as key components of peptidomimetic protease inhibitors.

It is observed that one enantiomer of a N-protected phenyl-Gly can increase the fluorescence intensity of the binaphthyl fluorophores, but the other enantiomer does not cause much fluorescence enhancement. 143 a-Amino acids labeled with short-lived positron emitters carbon-11 (t1/2 = 20 min) and fluorine-18 (t1/2 = 110 min) have been extensively used for the visualization of tumors, measurements of protein synthesis rates, and amino acid decarboxylation rates in humans using positron emission tomography (PET).

Bicyclic a-amino acids prepared in this way included cis- and trans-perhydroisoquinoline-3-carboxylic acids and cis-perhydro-2-pyrindine-3-carboxylic acids of various substitutions and oxidation levels. 6 Halogenoalkyl a-amino acids The incorporation of fluoride can have dramatic effects on peptide stability and protein–protein interactions. b-Fluorinated amino acids have gained prominence as mechanism-based inhibitors of amino acid decarboxylases and transaminases. Ca-Fluoroalkyl substituted amino acids bearing a fluorinated substituent instead of the a-proton are known to be able to increase metabolic stability as well as stabilize the secondary structure of the peptide.

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Amino Acids, Peptides and Proteins (SPR Amino Acids, Peptides, and Proteins (RSC)) (Vol 36) by John S. Davies


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