By John S. Davies
Fundamental reference resource for researchers within the pharmaceutical and allied industries, and on the biology/chemistry interface in academia. summary: fundamental reference resource for researchers within the pharmaceutical and allied industries, and on the biology/chemistry interface in academia. learn more...
Read or Download Amino Acids, Peptides and Proteins (SPR Amino Acids, Peptides, and Proteins (RSC)) (Vol 36) PDF
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Extra info for Amino Acids, Peptides and Proteins (SPR Amino Acids, Peptides, and Proteins (RSC)) (Vol 36)
69 The synthesis of enantiopure g-substituted g-amino acids with proteinogenic side chains, starting from the corresponding natural a-amino acids, was studied. N-Protected amino aldehydes containing various protective groups were directly reacted with methyl, benzyl, and tert-butyl phosphoranylidene acetate to produce a,b-unsaturated g-amino esters. 170 Recently, b-hydroxy-g-amino acids have received considerable attention, notably those acting as key components of peptidomimetic protease inhibitors.
It is observed that one enantiomer of a N-protected phenyl-Gly can increase the ﬂuorescence intensity of the binaphthyl ﬂuorophores, but the other enantiomer does not cause much ﬂuorescence enhancement. 143 a-Amino acids labeled with short-lived positron emitters carbon-11 (t1/2 = 20 min) and ﬂuorine-18 (t1/2 = 110 min) have been extensively used for the visualization of tumors, measurements of protein synthesis rates, and amino acid decarboxylation rates in humans using positron emission tomography (PET).
Bicyclic a-amino acids prepared in this way included cis- and trans-perhydroisoquinoline-3-carboxylic acids and cis-perhydro-2-pyrindine-3-carboxylic acids of various substitutions and oxidation levels. 6 Halogenoalkyl a-amino acids The incorporation of ﬂuoride can have dramatic eﬀects on peptide stability and protein–protein interactions. b-Fluorinated amino acids have gained prominence as mechanism-based inhibitors of amino acid decarboxylases and transaminases. Ca-Fluoroalkyl substituted amino acids bearing a ﬂuorinated substituent instead of the a-proton are known to be able to increase metabolic stability as well as stabilize the secondary structure of the peptide.
Amino Acids, Peptides and Proteins (SPR Amino Acids, Peptides, and Proteins (RSC)) (Vol 36) by John S. Davies