Download e-book for kindle: Anthracycline antibiotics : new analogues, methods of by Waldemar Priebe, editor

By Waldemar Priebe, editor

ISBN-10: 0841230404

ISBN-13: 9780841230408

Unresolved structure-activity relationships in anthracycline analogue improvement / Edward M. Acton --
Non-cross-resistant anthracyclines with diminished basicity and elevated balance of the glycosidic bond / Waldemar Priebe, Piotr Skibicki, Oscar Varela, Nouri Neamati, Marcos Sznaidman, Krzysztof Dziewiszek, Grzegorz Grynkiewicz, Derek Horton, Yiyu Zou, Yi-He Ling, and Roman Perez-Soler --
Fluorinated anthracyclinones and their glycosylated items / Antonio Guidi, Franca Canfarini, Alessandro Giolitti, Franco Pasqui, Vittorio Pestellini, and Federico Arcamone --
Semisynthetic rhodomycins and anthracycline prodrugs / Cenek Kolar, Klaus Bosslet, Jörg Czech, Manfred Gerken, Peter Hermentin, Dieter Hoffmann, and Hans-Harold Sedlacek --
Synthetic techniques for reversal of anthracycline resistance and cardiotoxicity / Claude Monneret, Jean-Claude Florent, Jean-Pierre Gesson, Jean-Claude Jacquesy, François Tillequin, and Michel Koch --
Synthesis and organic actions of fluorinated daunorubicin and doxorubicin analogues / Tsutomu Tsuchiya and Yasushi Takagi --
Redox chemistry of anthracyclines and use of oxomorpholinyl radicals / Tad H. Koch and Giorgio Gaudiano --
Synthesis of anthraquinone analogues of associated anthracycline / Ping Ge and Richard A. Russell --
Synthesis and learn of structure-activity relationships of latest periods of anthracyclines / Antonino Suarato, Francesco Angelucci, Alberto Bargiotti, Michele Caruso, Daniela Faiardi, Laura Capolongo, Cristina Geroni, Marina Ripamonti, and Maria Grandi --
Molecular acceptance of DNA through daunorubicin / Jonathan B. Chaires --
Adducts of DNA and anthracycline antibiotics : buildings, interactions, and actions / Jasmine Y.-T. Wang, Mark Chao, and Andrew H.-J. Wang --
DNA topoisomerases and their inhibition by way of anthracyclines / Yves Pommier --
Anthracycline antihelicase motion : new mechanism with implications for guanosine-cytidine intercalation specificity / Nicholas R. Bachur, Robin Johnson, Fang Yu, Robert Hickey, and Linda Malkas --
Membrane biophysical parameters influencing anthracycline motion / Ratna Mehta and Thomas G. Burke --
Signal transduction platforms in doxorubicin hydrochloride mechanism of motion / Paul Vichi, James track, Jean Hess, and Thomas R. Tritton --
Analysis of multidrug transporter in residing cells : software to uptake and liberate of anthracycline derivatives via drug-resistant K562 cells / Arlette Garnier-Suillerot, Frédéric Frézard, Marie-Nicole Borrel, Elene Pereira, Jolanta Tarasiuk, and Marina Fiallo --
Role of reactive-oxygen metabolism in cardiac toxicity of anthracycline antibiotics / James H. Doroshow --
Amelioration of anthracycline-induced cardiotoxicity by way of natural chemical substances / Donald T. Witiak and Eugene H. Herman --
Use of drug companies to ameliorate the healing index of anthracycline antibiotics / Roman Perez-Soler, Steven Sugarman, Yiyu Zou, and Waldemar Priebe

Show description

Read or Download Anthracycline antibiotics : new analogues, methods of delivery, and mechanisms of action : developed from a symposium sponsored by the Division of Carbohydrate Chemistry at the 205th National Meeting of the American Chemical Society, Denver, Colorado, Mar PDF

Similar action books

The Swords of Babylon (Matt Drake, Book 6) - download pdf or read online

Publication 6 within the Matt Drake sequence. those books could be learn within the right order.

A final stand is coming – a conflict of battles.

Matt Drake and the SPEAR workforce go back in a new action-packed experience!

When Drake is captured and despatched to a distant Russian felony, little does he be aware of that the final final member of the Shadow Elite has already set in movement a reckless, uncompromising plan to manage or spoil all existence in the world.

The conflict for the survival of the human race starts in historical Babylon, the place Alexander the good came across and warned of a moment approach to turn on Odin’s doomsday equipment. His resolution used to be to forge seven swords of Babylon and attach them to the Tower of Babel. Drake's workforce input a dangerous race to discover and detect how you can use those swords to strive against the catastrophically robust weapon of the gods earlier than it's too overdue. in the event that they fail and the doomsday machine is activated, the area will burn.

Through excessive camaraderie, betrayal, and unending twists and turns, the group release a rescue try out for Drake, then face skirmishes in Russia’s pink sq., and fights one of the ruins of Babylon till they arrive to a last determined conflict the place all 3 tombs and the darkest black gap in lifestyles – the traditional Pit of Babylon – need to be assaulted concurrently.

The destiny of the realm hangs within the stability.

Repulse Monkey (Alex Glauberman, Book 2) - download pdf or read online

"“Step again to Repulse Monkey,” is the identify of a tai chi place, person who Boston-based car mechanic Alex Glauberman reveals quite apt, in his given situations. It’s now a 12 months for the reason that Alex’s first brush with homicide and detection stated in go back TO SENDER.

Download e-book for iPad: Steroid Hormone Action and Cancer by Roy Hertz (auth.), K. M. J. Menon, Jerry R. Reel (eds.)

This quantity is an outgrowth of a symposium held on the collage of Michigan, Ann Arbor, Michigan, October 27-29, 1975. This symposium was once geared up to compile simple scientists and clinicians for the aim of changing new principles and the newest details within the region of Steroid Hormone motion and melanoma.

Additional resources for Anthracycline antibiotics : new analogues, methods of delivery, and mechanisms of action : developed from a symposium sponsored by the Division of Carbohydrate Chemistry at the 205th National Meeting of the American Chemical Society, Denver, Colorado, Mar

Example text

3'-Hydroxy Anthracyclines Halogenated at the C-2' Position / 2'-Iodo-3 -deamino Daunorubicins. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1994. 28 A N T H R A C Y C L I N E ANTIBIOTICS that series were 2'-iodo daunorubicins having a-L-talo and a-L-manno configurations (33, 38, 41, 44). In a one-step reaction, daunomycinone was coupled with 3,4-di-O-acetyl-L-fucal (3) in the presence of N-iodosuccinimide (NIS) to give 2'-iodo-3',4'-diacetoxy-a-L-ffl/o-daunorubicin 35. AcO-—ο NIS OAc CH3O 36 CH3O Ο OH OH 9 Ο OH Ο CH3O AcO^o I Ο OH Ο AcO /CH3 AcCT-O AcO 37 (a-L-manno) 38 (fr-L-gluco) HO I 39 (WP8) SCHEME 5 A similar reaction with 3,4-di-O-acetyl-L-rhamnal (36) (Scheme 5) gave two 2'-iodo trans addition products having a-L-manno (37) and β-L-g/wco (38) configurations.

Similarly, the corresponding derivative in the natural (daunorubicin) series was obtained starting from 16b (in the optically active form). The two compounds were therefore chosen as intermediates for the synthesis of 8-(S)-fluoro-anthracyclines 17a and 17b. Compound 16a was synthesized in four steps (Figure 2), at a 52% overall yield, from the readily available l,4-dimethoxy-2,3-bis-(bromomethyl)anthraquinone, following an adaptation of Cava's route to anthracyclinones (25). The introduction of fluorine was then accomplished by means of the Olah's reagent and the desired fluorohydrin (Figure 3) was obtained in 60% yield (26).

32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. 47. 48. 49. 50. ET AL. ; Neamati, N . ; Perez-Soler, R. J. Antibiot. 1990, 43, 838. ; Priebe, W. Cancer Chemother. Pharmacol. 1992, 30, 267. ; Pommier, Y. Int. J. Cancer, 1994, 58, 85-94. Chaires, J. ; Graves, D. ; Burke, T. G. J. Am. Chem. Soc. 1993, 115, 5360. Friedman, R. A. ; Manning, G. Biopolymers 1984, 23, 2671. ; Wright, H . ; Sweatman, T. ; Israel, M . Oncol. Res. 1992, 4, 343. ; Sweatman, T. ; Docter, M . ; Israel, M . Cancer Res.

Download PDF sample

Anthracycline antibiotics : new analogues, methods of delivery, and mechanisms of action : developed from a symposium sponsored by the Division of Carbohydrate Chemistry at the 205th National Meeting of the American Chemical Society, Denver, Colorado, Mar by Waldemar Priebe, editor

by Mark

Rated 4.36 of 5 – based on 26 votes